About zoledronic acid
Zoledronic acid is a medication we use to treat osteoporosis. Osteoporosis is a condition that weakens bones and increases the risk of fractures.
Zoledronic acid helps to strengthen bones by slowing down the process that causes bone loss.
Following your recent fracture, we believe you will benefit from this treatment.
How we give it
We give patients zoledronic acid once a year, as an intravenous infusion. This means we inject it into your vein. The infusion lasts about 15 minutes and we monitor you for any reactions while it is underway.
Preparing for your infusion
Zoledronic acid can affect your kidneys. We always check your kidney function before your infusion.
Important
To reduce the risk of kidney problems, we recommend you drink plenty of fluids.
If possible, try to drink 6 to 8 glasses of water on the day of your infusion.
Benefits and side effects
The benefits and possible side effects are as follows.
Benefits
Zoledronic acid helps to make your bones stronger. Six months after treatment, a single infusion of Zoledronic acid can reduce the risk of fracture for 23 out of 100 people. Its effect continues for 2 to 3 years.
Side effects
Common
- Flu-like symptoms, headache, joint or muscle pain for 3 to 5 days after the infusion. We recommend you take paracetamol for a day or two afterwards, to minimise potential side effects.
Rare (1 in 1,000 people)
- Low blood calcium levels (hypocalcaemia). We ensure your calcium and vitamin D levels are normal before your infusion. We will prescribe vitamin D and calcium supplements, and you should continue to take them long-term.
- ONJ (osteonecrosis of the jaw). This means healing in the mouth is delayed (for example after major dental surgery). We advise you to maintain good oral (mouth) hygiene and have regular dental check-ups.
- Atypical fracture. This is a type of thigh bone fracture that can occur after many years of treatment. Seek medical help if this happens.
Follow-up
After treatment, we will schedule a follow-up appointment for you. The timing of this depends on your health condition and mobility.
More information
For more guidance, visit the Royal Osteoporosis Society information on zoledronic acid.
Contact information
Kingston Hospital Plaster Room
Kingston Hospital Cambridge ward
Kingston Hospital Hub team for appointments